AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-κB signalling pathway
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چکیده
منابع مشابه
The Type III Secretion Effector NleE Inhibits NF-κB Activation
The complex host-pathogen interplay involves the recognition of the pathogen by the host's innate immune system and countermeasures taken by the pathogen. Detection of invading bacteria by the host leads to rapid activation of the transcription factor NF-kappaB, followed by inflammation and eradication of the intruders. In response, some pathogens, including enteropathogenic Escherichia coli (E...
متن کاملAeromonas salmonicida subsp. salmonicida type strain does not possess a type III secretion system.
A study by Chacón et al. examined the presence of type III secretion genes in Aeromonas species of clinical significance (2). The authors demonstrated, by dot blot hybridization at 50°C, that the prevalence of these genes was high in clinical strains of A. hydrophila and A. veronii, particularly those isolated from extraintestinal infections. However, the positive control used in this study was...
متن کاملContribution of the type III secretion system (TTSS) to virulence of Aeromonas salmonicida subsp. salmonicida.
The recently described type III secretion system (TTSS) of Aeromonas salmonicida subsp. salmonicida has been linked to virulence in salmonids. In this study, three TTSS effector genes, aexT, aopH or aopO, were inactivated by deletion, as was ascC, the gene encoding the outer-membrane pore of the secretion apparatus. Effects on virulence were assayed by live challenge of Atlantic salmon (Salmo s...
متن کاملEvidence for a type III secretion system in Aeromonas salmonicida subsp. salmonicida.
Aeromonas salmonicida subsp. salmonicida, the etiological agent of furunculosis, is an important fish pathogen. We have screened this bacterium with a broad-host-range probe directed against yscV, the gene that encodes the archetype of a highly conserved family of inner membrane proteins found in every known type III secretion system. This has led to the identification of seven open reading fra...
متن کاملA Family of Salmonella Type III Secretion Effector Proteins Selectively Targets the NF-κB Signaling Pathway to Preserve Host Homeostasis.
Microbial infections usually lead to host innate immune responses and inflammation. These responses most often limit pathogen replication although they can also result in host-tissue damage. The enteropathogenic bacteria Salmonella Typhimurium utilizes a type III secretion system to induce intestinal inflammation by delivering specific effector proteins that stimulate signal transduction pathwa...
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ژورنال
عنوان ژورنال: Microbiology
سال: 2006
ISSN: 1350-0872,1465-2080
DOI: 10.1099/mic.0.28889-0